Ruthenium-Catalyzed Regio- and Enantioselective Allylic Substitution with Water: Direct Synthesis of Chiral Allylic Alcohols

Authors

  • Naoya Kanbayashi,

    1. Department of Macromolecular Science, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka 560-0043 (Japan), Fax: (+81) 6-6850-5474
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  • Prof. Kiyotaka Onitsuka

    Corresponding author
    1. Department of Macromolecular Science, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka 560-0043 (Japan), Fax: (+81) 6-6850-5474
    • Department of Macromolecular Science, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka 560-0043 (Japan), Fax: (+81) 6-6850-5474
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  • This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (Japan) and partly by the Sumitomo Foundation.

Abstract

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Less is more: A new route to access chiral allylic alcohols through the regio- and enantioselective substitution of monosubstituted allylic chlorides with water has been developed. The reaction is catalyzed effectively by planar-chiral cyclopentadienyl ruthenium complexes (see scheme).

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