We are grateful to the National Institute of General Medical Sciences of the National Institutes of Health (GM-068649) for support.
Synthesis of Atropisomerically Defined, Highly Substituted Biaryl Scaffolds through Catalytic Enantioselective Bromination and Regioselective Cross-Coupling†
Article first published online: 21 APR 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 22, pages 5125–5129, May 23, 2011
How to Cite
Gustafson, J. L., Lim, D., Barrett, K. T. and Miller, S. J. (2011), Synthesis of Atropisomerically Defined, Highly Substituted Biaryl Scaffolds through Catalytic Enantioselective Bromination and Regioselective Cross-Coupling. Angew. Chem. Int. Ed., 50: 5125–5129. doi: 10.1002/anie.201101147
- Issue published online: 16 MAY 2011
- Article first published online: 21 APR 2011
- Manuscript Received: 15 FEB 2011
- National Institute of General Medical Sciences
- National Institutes of Health. Grant Number: GM-068649
- cross-coupling reactions;
A selective sequence: An enantioselective synthesis (see scheme) of atropisomerically defined p-terphenyls, as well as tetra- and pentaaryl compounds is reported. The synthesis proceeds through sequential atropisomer-selective electrophilic aromatic substitution and regioselective palladium-catalyzed cross-coupling reactions.