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Keywords:

  • antimalarial agents;
  • cytotoxic agents;
  • natural products;
  • photocycloaddition
Thumbnail image of graphical abstract

Photons in action: Cascade sequences, brevity, and efficiency are the hallmarks of the synthesis of a functionalized tricyclo[9.3.0.0]tetradecane ring system of the marine natural product bielschowskysin. The synthesis is achieved in five steps, with the key step being an exquisite intramolecular [2+2] photocycloaddition of a macrocyclic precursor (see scheme).