Suzuki–Miyaura Cross-Coupling Reactions in Flow: Multistep Synthesis Enabled by a Microfluidic Extraction


  • T.N., S.K., A.J.M., K.F.J., and S.L.B. thank the Novartis International AG for funding. T.N. is a Fulbright Postdoctoral Fellow. S.K. acknowledges funding from the Swiss National Science Foundation (SNF). A.J.M. is an Undergraduate Research Opportunities Program (U.R.O.P.) student at Massachusetts Institute of Technology.


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Continuous success: A continuous-flow Suzuki–Miyaura cross-coupling reaction starting from phenols was made possible through use of an efficient microfluidic extraction operation and a packed-bed reactor. Various biaryls were obtained in excellent yield (14 examples). TBAB=Bu4N+Br.