These authors contributed equally to this work.
Multiple-Interaction Ligands Inspired by Mussel Adhesive Protein: Synthesis of Highly Stable and Biocompatible Nanoparticles†
Article first published online: 16 SEP 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 48, pages 11360–11365, November 25, 2011
How to Cite
Ling, D., Park, W., Park, Y. I., Lee, N., Li, F., Song, C., Yang, S.-G., Choi, S. H., Na, K. and Hyeon, T. (2011), Multiple-Interaction Ligands Inspired by Mussel Adhesive Protein: Synthesis of Highly Stable and Biocompatible Nanoparticles. Angew. Chem. Int. Ed., 50: 11360–11365. doi: 10.1002/anie.201101521
We thank Prof. Jeffery Pyun, Dr. Jeong Hyun Kim, Dr. Soongu Kwon, and Dr. Youngjin Jang for valuable discussions. T.H. acknowledges financial support by the Korean Ministry of Education, Science and Technology through Strategic Research (2010-0029138), and World Class University (R31-10013) Programs of National Research Foundation (NRF) of Korea, and the financial support by Hanwha Chemical Co. K.N. acknowledges financial support from the Fundamental R&D Program for Core Technology of Materials of the Ministry of Knowledge Economy of Korea. Y.I.P and W.P acknowledge the Hi Seoul Science Fellowship from the Seoul Scholarship Foundation.
- Issue published online: 18 NOV 2011
- Article first published online: 16 SEP 2011
- Manuscript Revised: 22 AUG 2011
- Manuscript Received: 2 MAR 2011
- Korean Ministry of Education, Science and Technology. Grant Numbers: 2010-0029138, R31-10013
- Programs of National Research Foundation (NRF) of Korea
- Ministry of Knowledge Economy of Korea
- contrast agents;
- coordination modes;
All bound up: A poly(L-3,4-dihydroxyphenylalanine)-based ligand converts hydrophobic nanoparticles into hydrophilic and biocompatible species through several binding modes. Nanoparticles functionalized with this ligand (see picture) are highly stable in various aqueous solutions. A successful in vivo MRI application using functionalized Fe3O4 nanoparticles confirmed their suitability for various biomedical applications.