Communication

Multiple-Interaction Ligands Inspired by Mussel Adhesive Protein: Synthesis of Highly Stable and Biocompatible Nanoparticles†

  1. Daishun Ling1,‡,
  2. Wooram Park2,‡,
  3. Yong Il Park1,
  4. Nohyun Lee1,
  5. Fangyuan Li2,
  6. Changyeong Song1,
  7. Prof. Su-Geun Yang4,
  8. Prof. Seung Hong Choi3,
  9. Prof. Kun Na2,*,
  10. Prof. Taeghwan Hyeon1,*

Article first published online: 16 SEP 2011

DOI: 10.1002/anie.201101521

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 48, pages 11360–11365, November 25, 2011

Additional Information

How to Cite

Ling, D., Park, W., Park, Y. I., Lee, N., Li, F., Song, C., Yang, S.-G., Choi, S. H., Na, K. and Hyeon, T. (2011), Multiple-Interaction Ligands Inspired by Mussel Adhesive Protein: Synthesis of Highly Stable and Biocompatible Nanoparticles. Angew. Chem. Int. Ed., 50: 11360–11365. doi: 10.1002/anie.201101521

Author Information

  1. 1

    World Class University (WCU) program of Chemical Convergence for Energy & Environment (C2E2) and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (Korea)

  2. 2

    Department of Biotechnology, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743 (Korea)

  3. 3

    Diagnostic Radiology, Seoul National University Hospital, and Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744 (Korea)

  4. 4

    Department of Applied Bioscience, CHA University, Seoul 135-081 (Korea)

  1. ‡

    These authors contributed equally to this work.

*Department of Biotechnology, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743 (Korea)

  1. †

    We thank Prof. Jeffery Pyun, Dr. Jeong Hyun Kim, Dr. Soongu Kwon, and Dr. Youngjin Jang for valuable discussions. T.H. acknowledges financial support by the Korean Ministry of Education, Science and Technology through Strategic Research (2010-0029138), and World Class University (R31-10013) Programs of National Research Foundation (NRF) of Korea, and the financial support by Hanwha Chemical Co. K.N. acknowledges financial support from the Fundamental R&D Program for Core Technology of Materials of the Ministry of Knowledge Economy of Korea. Y.I.P and W.P acknowledge the Hi Seoul Science Fellowship from the Seoul Scholarship Foundation.

  2. ‡

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 18 NOV 2011
  2. Article first published online: 16 SEP 2011
  3. Manuscript Revised: 22 AUG 2011
  4. Manuscript Received: 2 MAR 2011

Funded by

  • Korean Ministry of Education, Science and Technology. Grant Numbers: 2010-0029138, R31-10013
  • Programs of National Research Foundation (NRF) of Korea
  • Ministry of Knowledge Economy of Korea

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Keywords:

  • biocompatibility;
  • contrast agents;
  • coordination modes;
  • nanoparticles;
  • polymers
Thumbnail image of graphical abstract

All bound up: A poly(L-3,4-dihydroxyphenylalanine)-based ligand converts hydrophobic nanoparticles into hydrophilic and biocompatible species through several binding modes. Nanoparticles functionalized with this ligand (see picture) are highly stable in various aqueous solutions. A successful in vivo MRI application using functionalized Fe3O4 nanoparticles confirmed their suitability for various biomedical applications.

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