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In Situ Generated (Hypo)Iodite Catalysts for the Direct α-Oxyacylation of Carbonyl Compounds with Carboxylic Acids


  • Financial support for this project was provided by JSPS.KAKENHI (20245022, 22750087), NEDO, the Society of Iodine Science, JSPS Research Fellowships for Young Scientists (T.Y.), and the Global COE Program of MEXT.


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It′s the iodine: The intra- and intermolecular title reaction is catalyzed by an in situ generated ammonium (hypo)iodite species. Either H2O2 or tert-butyl hydroperoxide (TBHP) can be used as an environmentally benign oxidant and a wide range of substrates react to give the corresponding α-acyloxycarbonyl compounds in good to excellent yields.