pH-Tunable Calcium Phosphate Covered Mesoporous Silica Nanocontainers for Intracellular Controlled Release of Guest Drugs

Authors

  • Hwa Pyeong Rim,

    1. Department of Life and Nanopharmaceutical Science, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701 (Korea)
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Kyung Hyun Min,

    1. Department of Life and Nanopharmaceutical Science, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701 (Korea)
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Hong Jae Lee,

    1. Department of Maxillofacial Biomedical Engineering & Institute of Oral Biology, School of Dentistry, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701 (Korea)
    Search for more papers by this author
  • Prof. Dr. Seo Young Jeong,

    Corresponding author
    1. Department of Life and Nanopharmaceutical Science, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701 (Korea)
    • Department of Life and Nanopharmaceutical Science, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701 (Korea)
    Search for more papers by this author
  • Prof. Dr. Sang Cheon Lee

    Corresponding author
    1. Department of Maxillofacial Biomedical Engineering & Institute of Oral Biology, School of Dentistry, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701 (Korea)
    • Department of Maxillofacial Biomedical Engineering & Institute of Oral Biology, School of Dentistry, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701 (Korea)
    Search for more papers by this author

  • This research was supported by a grant (code: 2011K000186) from the Center for Nanostructured Materials Technology under the “21st Century Frontier R&D Programs” of the Ministry of Education, Science, and Technology, Korea.

Abstract

original image

Springing the trap: A pH-responsive mesoporous silica nanoparticle with a calcium phosphate (CaP) pore-blocking coating was developed by enzyme-mediated surface mineralization under mild conditions. Upon exposure to cellular lysosomal pH, guest anticancer drug was released from the pore by dissolution of the CaP pore blocker (see picture; HAp=hydroxyapatite).

Ancillary