These authors contributed equally to this work.
pH-Tunable Calcium Phosphate Covered Mesoporous Silica Nanocontainers for Intracellular Controlled Release of Guest Drugs†
Article first published online: 8 AUG 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 38, pages 8853–8857, September 12, 2011
How to Cite
Rim, H. P., Min, K. H., Lee, H. J., Jeong, S. Y. and Lee, S. C. (2011), pH-Tunable Calcium Phosphate Covered Mesoporous Silica Nanocontainers for Intracellular Controlled Release of Guest Drugs. Angew. Chem. Int. Ed., 50: 8853–8857. doi: 10.1002/anie.201101536
This research was supported by a grant (code: 2011K000186) from the Center for Nanostructured Materials Technology under the “21st Century Frontier R&D Programs” of the Ministry of Education, Science, and Technology, Korea.
- Issue published online: 8 SEP 2011
- Article first published online: 8 AUG 2011
- Manuscript Revised: 31 MAY 2011
- Manuscript Received: 2 MAR 2011
- Center for Nanostructured Materials Technology. Grant Number: 2011K000186
- Ministry of Education, Science, and Technology, Korea
- drug delivery;
- host–guest systems;
- mesoporous materials;
Springing the trap: A pH-responsive mesoporous silica nanoparticle with a calcium phosphate (CaP) pore-blocking coating was developed by enzyme-mediated surface mineralization under mild conditions. Upon exposure to cellular lysosomal pH, guest anticancer drug was released from the pore by dissolution of the CaP pore blocker (see picture; HAp=hydroxyapatite).