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Bio-orthogonal “Double-Click” Chemistry Based on Multifunctional Coatings

Authors

  • Xiaopei Deng,

    1. Departments of Chemical Engineering, Materials Science and Engineering, Macromolecular Science and Engineering and Biomedical Engineering, University of Michigan, Ann Arbor, 48109 (USA)
    2. Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany), Fax: (+1) 734-764-7453
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  • Dr. Christian Friedmann,

    1. Departments of Chemical Engineering, Materials Science and Engineering, Macromolecular Science and Engineering and Biomedical Engineering, University of Michigan, Ann Arbor, 48109 (USA)
    2. Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany), Fax: (+1) 734-764-7453
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  • Prof. Dr. Joerg Lahann

    Corresponding author
    1. Departments of Chemical Engineering, Materials Science and Engineering, Macromolecular Science and Engineering and Biomedical Engineering, University of Michigan, Ann Arbor, 48109 (USA)
    2. Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany), Fax: (+1) 734-764-7453
    • Departments of Chemical Engineering, Materials Science and Engineering, Macromolecular Science and Engineering and Biomedical Engineering, University of Michigan, Ann Arbor, 48109 (USA)
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Abstract

original image

Double “click”: Two different molecules can be sequentially immobilized on defined areas of the same surface by utilizing the different reactivity of activated and non-activated alkynyl groups (see picture). The reactions were carried out at room temperature in water, with the first immobilization step being catalyst-free and the second step requiring CuI as a catalyst.

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