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Keywords:

  • nanostructures;
  • silver;
  • single-molecule detection;
  • surface-enhanced Raman scattering;
  • surface plasmon resonance
Thumbnail image of graphical abstract

Getting hotter: Hot spots that enable detection of surface-enhanced Raman scattering (SERS) from a single molecule can form at the nanocube–substrate interface by simply depositing a silver nanocube onto a metal substrate (see picture). This new approach offers great simplicity for the formation of robust and fully accessible hot spots, thus providing an effective platform for ultrasensitive detection.