Generation of Hot Spots with Silver Nanocubes for Single-Molecule Detection by Surface-Enhanced Raman Scattering


  • This work was supported in part by a research grant from the NSF (DMR-0804088) and a 2006 Director’s Pioneer Award from the NIH (DP1 OD000798). Part of the research was performed at the Nano Research Facility, a member of the National Nanotechnology Infrastructure Network (NNIN), which is supported by the NSF under ECS-0335765.


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Getting hotter: Hot spots that enable detection of surface-enhanced Raman scattering (SERS) from a single molecule can form at the nanocube–substrate interface by simply depositing a silver nanocube onto a metal substrate (see picture). This new approach offers great simplicity for the formation of robust and fully accessible hot spots, thus providing an effective platform for ultrasensitive detection.