Get access

Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding

Authors


  • We thank the NHRMC for financial support.

Abstract

original image

Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously “unfoldable” miniprotein with therapeutic potential (see picture). This simple strategy should generally facilitate the folding of peptides and proteins with multiple disulfide bonds.

Ancillary