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Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding


  • We thank the NHRMC for financial support.


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Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously “unfoldable” miniprotein with therapeutic potential (see picture). This simple strategy should generally facilitate the folding of peptides and proteins with multiple disulfide bonds.