Communication

Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery†

  1. Dr. Nina Svensen1,
  2. Dr. Juan José Díaz-Mochón1,
  3. Dr. Kevin Dhaliwal2,
  4. Songsak Planonth1,
  5. Dr. Michael Dewar3,
  6. Dr. J. Douglas Armstrong3,
  7. Prof. Mark Bradley1,*

Article first published online: 17 MAY 2011

DOI: 10.1002/anie.201101804

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 27, pages 6133–6136, June 27, 2011

Additional Information

How to Cite

Svensen, N., Díaz-Mochón, J. J., Dhaliwal, K., Planonth, S., Dewar, M., Armstrong, J. D. and Bradley, M. (2011), Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery. Angew. Chem. Int. Ed., 50: 6133–6136. doi: 10.1002/anie.201101804

Author Information

  1. 1

    School of Chemistry, The University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ (UK), Fax: (+44) 131-650-6453

  2. 2

    MRC Centre for Inflammation Research, The University of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA (UK)

  3. 3

    School of Informatics, The University of Edinburgh, 10 Crichton Street, Edinburgh, EH8 9AB (UK)

*School of Chemistry, The University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ (UK), Fax: (+44) 131-650-6453

  1. †

    We thank the EPSRC and BBSRC for funding.

Publication History

  1. Issue published online: 21 JUN 2011
  2. Article first published online: 17 MAY 2011
  3. Manuscript Received: 14 MAR 2011

Funded by

  • EPSRC
  • BBSRC

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Keywords:

  • drug delivery;
  • homing peptides;
  • microarrays;
  • peptide nucleic acids;
  • peptides
Thumbnail image of graphical abstract

To the point: The identification of peptides to optimize both the delivery and tumor penetration of existing cancer drugs in a cell-selective manner would be highly desirable. The screening of a peptide nucleic acid (PNA)-encoded peptide library (see picture) now allows the identification of versatile cell homing peptides for any cell type of interest.

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