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Functional Assignment of an Enzyme that Catalyzes the Synthesis of an Archaea-Type Ether Lipid in Bacteria

Authors


  • We thank Josef Kiermaier for MS measurements, Fritz Kastner and Dr. Markus Schmid for NMR measurements and analysis, Prof. Dr. Michael Hecker and Dr. Christian Vogl for providing B.subtilis strains, Stéphanie Garcia for experimental assistance, and David Peterhoff, Prof. Drs. Jörg Heilmann, Ludwig Lehle, and Widmar Tanner for discussion and comments on the manuscript. This work was supported by a research grant from the Deutsche Forschungsgemeinschaft to P.B. (BA 3943/1-1) and a PhD fellowship from the Konrad-Adenauer-Stiftung to H.G.

Abstract

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An archaea-type ether lipid in bacteria: PcrB, the bacterial homologue of the archaea-specific geranylgeranylglyceryl phosphate synthase, produces heptaprenylglyceryl phosphate in bacillales. The product becomes dephosphorylated and acetylated in vivo.

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