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Keywords:

  • enolsilanes;
  • photoredox catalysis;
  • α-perfluoroalkylation;
  • α-trifluoromethylation
Thumbnail image of graphical abstract

A facile and efficient method for the α-trifluoromethylation of carbonyl compounds and enolsilanes has been accomplished through application of a photoredox catalysis strategy. A one-flask procedure for the direct α-trifluoromethylation and α-perfluoroalkylation of ketone, amide, and ester substrates as well as silylketene acetals is described (see scheme).