These authors contributed equally.
Total Chemical Synthesis of a 304 Amino Acid K48-Linked Tetraubiquitin Protein†
Article first published online: 18 MAY 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 27, pages 6137–6141, June 27, 2011
How to Cite
Kumar, K. S. A., Bavikar, S. N., Spasser, L., Moyal, T., Ohayon, S. and Brik, A. (2011), Total Chemical Synthesis of a 304 Amino Acid K48-Linked Tetraubiquitin Protein. Angew. Chem. Int. Ed., 50: 6137–6141. doi: 10.1002/anie.201101920
This work was supported by the Edmond J. Safra Foundation.
- Issue published online: 21 JUN 2011
- Article first published online: 18 MAY 2011
- Manuscript Received: 18 MAR 2011
- Edmond J. Safra Foundation
- amino acids;
- ubiquitin chains
A new record: The largest chemically synthesized polypeptide composed of 304 residues, which corresponds to folded K48-tetraubiquitin, has been achieved (see scheme). The presented synthetic method could be applied to any of the remaining tetraubiquitin chains, and should ultimately assist ongoing efforts to unravel how the remarkable diversity of ubiquitin signaling is achieved.