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Assembly of Substituted 2-Alkylquinolines by a Sequential Palladium-Catalyzed C[BOND]N and C[BOND]C Bond Formation

Authors

  • Prof. Dr. Yoshio Matsubara,

    Corresponding author
    1. Faculty of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka, 577-8502 (Japan), Fax: (+81) 6-6727-2024
    • Faculty of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka, 577-8502 (Japan), Fax: (+81) 6-6727-2024
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  • Saori Hirakawa,

    1. Faculty of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka, 577-8502 (Japan), Fax: (+81) 6-6727-2024
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  • Prof. Dr. Yoshihiro Yamaguchi,

    1. Faculty of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka, 577-8502 (Japan), Fax: (+81) 6-6727-2024
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  • Prof. Dr. Zen-ichi Yoshida

    Corresponding author
    1. Faculty of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka, 577-8502 (Japan), Fax: (+81) 6-6727-2024
    • Faculty of Science and Engineering, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka, 577-8502 (Japan), Fax: (+81) 6-6727-2024
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Abstract

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Diversity: A range of substituted 2-alkylquinolines can be prepared in a general and efficient synthetic approach that employs mild reaction conditions (see scheme). The synthesis is based on a sequential palladium-catalyzed C[BOND]N and C[BOND]C bond formation, followed by palladium-catalyzed aromatization, and results in the formation of the desired compounds in one step.

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