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La/Ag Heterobimetallic Cooperative Catalysis: A Catalytic Asymmetric Conia-Ene Reaction


  • This work was financially supported by Grant-in-Aid for Scientific Research (S) from the JSPS. T.M. thanks the JSPS for a predoctoral fellowship. Dr. M. Shiro is gratefully acknowledged for X-ray crystallographic analysis of 3 a.


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A dual catalyst system: The cooperative function of a hard and soft Lewis acid (LaIII and AgI, respectively) in a catalyst system that includes an amide-based ligand 1 is crucial for simultaneous activation of intramolecular 1,3-dicarbonyl and alkyne moieties to afford enantioenriched cyclopentane derivatives (see scheme).

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