These authors contributed equally to this work.
Solid-Phase Synthesis of Sequence-Defined T-, i-, and U-Shape Polymers for pDNA and siRNA Delivery†
Article first published online: 11 AUG 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 38, pages 8986–8989, September 12, 2011
How to Cite
Schaffert, D., Troiber, C., Salcher, E. E., Fröhlich, T., Martin, I., Badgujar, N., Dohmen, C., Edinger, D., Kläger, R., Maiwald, G., Farkasova, K., Seeber, S., Jahn-Hofmann, K., Hadwiger, P. and Wagner, E. (2011), Solid-Phase Synthesis of Sequence-Defined T-, i-, and U-Shape Polymers for pDNA and siRNA Delivery. Angew. Chem. Int. Ed., 50: 8986–8989. doi: 10.1002/anie.201102165
This work was supported by the Cluster “Nanosystems Initiative Munich” and the Biotech Cluster m4 T12. I.M. was a visiting PhD student from IRB Barcelona.
- Issue published online: 8 SEP 2011
- Article first published online: 11 AUG 2011
- Manuscript Revised: 20 MAY 2011
- Manuscript Received: 28 MAR 2011
- Nanosystems Initiative Munich
Artificial oligo(ethylene amino) acids, together with selected natural amino acids and fatty acid modifications, have been used for the solid-phase-assisted synthesis of polymers with precise sequence, topology, and modifications (see picture). First proof-of-concept studies demonstrate the high potential of such polymers in pDNA and siRNA delivery. K=lysine, A=alanine.