Communication

Solid-Phase Synthesis of Sequence-Defined T-, i-, and U-Shape Polymers for pDNA and siRNA Delivery†

  1. Dr. David Schaffert1,‡,
  2. Christina Troiber1,‡,
  3. Eveline E. Salcher1,
  4. Thomas Fröhlich1,
  5. Irene Martin1,
  6. Dr. Naresh Badgujar1,
  7. Christian Dohmen1,
  8. Daniel Edinger1,
  9. Raphaela Kläger1,
  10. Dr. Gelja Maiwald1,
  11. Katarina Farkasova1,
  12. Dr. Silke Seeber2,
  13. Dr. Kerstin Jahn-Hofmann2,
  14. Dr. Philipp Hadwiger2,
  15. Prof. Ernst Wagner1,*

Article first published online: 11 AUG 2011

DOI: 10.1002/anie.201102165

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 38, pages 8986–8989, September 12, 2011

Additional Information

How to Cite

Schaffert, D., Troiber, C., Salcher, E. E., Fröhlich, T., Martin, I., Badgujar, N., Dohmen, C., Edinger, D., Kläger, R., Maiwald, G., Farkasova, K., Seeber, S., Jahn-Hofmann, K., Hadwiger, P. and Wagner, E. (2011), Solid-Phase Synthesis of Sequence-Defined T-, i-, and U-Shape Polymers for pDNA and siRNA Delivery. Angew. Chem. Int. Ed., 50: 8986–8989. doi: 10.1002/anie.201102165

Author Information

  1. 1

    Pharmaceutical Biotechnology, Center for Nanoscience, Ludwig-Maximilians-University Munich, Butenandtstrasse 5-13, 81377 Munich (Germany)

  2. 2

    Roche Kulmbach GmbH, Fritz Hornschuch-Strasse 9, 95386 Kulmbach (Germany)

  1. ‡

    These authors contributed equally to this work.

*Pharmaceutical Biotechnology, Center for Nanoscience, Ludwig-Maximilians-University Munich, Butenandtstrasse 5-13, 81377 Munich (Germany)

  1. †

    This work was supported by the Cluster “Nanosystems Initiative Munich” and the Biotech Cluster m4 T12. I.M. was a visiting PhD student from IRB Barcelona.

  2. ‡

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 8 SEP 2011
  2. Article first published online: 11 AUG 2011
  3. Manuscript Revised: 20 MAY 2011
  4. Manuscript Received: 28 MAR 2011

Funded by

  • Nanosystems Initiative Munich

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Keywords:

  • DNA;
  • polymers;
  • siRNA;
  • transfection
Thumbnail image of graphical abstract

Artificial oligo(ethylene amino) acids, together with selected natural amino acids and fatty acid modifications, have been used for the solid-phase-assisted synthesis of polymers with precise sequence, topology, and modifications (see picture). First proof-of-concept studies demonstrate the high potential of such polymers in pDNA and siRNA delivery. K=lysine, A=alanine.

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