The large water cascade (ital. cascare=to fall) in the baroque landscaped park Wilhelmshöhe in Kassel (Germany) is reminiscent of the blood-clotting cascade in which the different clotting factors initiate the formation of fibrin thrombi in an amplification cascade. This protective mechanism against blood loss is, however, also the cause of thrombotic diseases. In order to inhibit it an extensive search for low-molecular-weight factor Xa and thrombin inhibitors has been carried out. More on this in the Review by A. Straub et al. on page 4574 ff.
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.