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Molecular Self-Assembly of a Homopolymer: An Alternative To Fabricate Drug-Delivery Platforms for Cancer Therapy

Authors

  • Jinyao Liu,

    1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, State Key Laboratory of Metal Matrix Composites, 800 Dongchuan Road, Shanghai, 200240 (P. R. China)
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  • Prof. Dr. Wei Huang,

    Corresponding author
    1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, State Key Laboratory of Metal Matrix Composites, 800 Dongchuan Road, Shanghai, 200240 (P. R. China)
    • School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, State Key Laboratory of Metal Matrix Composites, 800 Dongchuan Road, Shanghai, 200240 (P. R. China)
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  • Yan Pang,

    1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, State Key Laboratory of Metal Matrix Composites, 800 Dongchuan Road, Shanghai, 200240 (P. R. China)
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  • Ping Huang,

    1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, State Key Laboratory of Metal Matrix Composites, 800 Dongchuan Road, Shanghai, 200240 (P. R. China)
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  • Prof. Dr. Xinyuan Zhu,

    1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, State Key Laboratory of Metal Matrix Composites, 800 Dongchuan Road, Shanghai, 200240 (P. R. China)
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  • Prof. Dr. Yongfeng Zhou,

    1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, State Key Laboratory of Metal Matrix Composites, 800 Dongchuan Road, Shanghai, 200240 (P. R. China)
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  • Prof. Dr. Deyue Yan

    Corresponding author
    1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, State Key Laboratory of Metal Matrix Composites, 800 Dongchuan Road, Shanghai, 200240 (P. R. China)
    • School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, State Key Laboratory of Metal Matrix Composites, 800 Dongchuan Road, Shanghai, 200240 (P. R. China)
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  • Financial support was provided by the National Basic Research Program (2007CB808000, 2009CB930400), National Natural Science Foundation of China (No. 21074069, 20874060, 50873058).

Abstract

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The best of both worlds: A novel amphiphilic homopolymer synthesized from a monomer consisting of a hydrophobic group (see picture, red) and a hydrophilic moiety (green) self-assembles in aqueous solution. The resulting micelles have a multi-core/shell structure and exhibit smart redox-responsive properties, thus providing a favorable drug delivery platform for cancer therapy.

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