The pick of the pockets: The first inhibitors for IspD, an enzyme from the non-mevalonate pathway of isoprenoid biosynthesis, are described. High-throughput-screening revealed a hit with an IC50 value of 140 nM. Co-crystal structure analyses of the binding mode in the newly formed allosteric pocket (see structure, red ball: water O atom), lead to the synthesis of a set of 17 derivatives which were tested to optimize the herbicidal activity.
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