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DNA-Linked Nanoparticle Building Blocks for Programmable Matter

Authors

  • Prof. Jin-Woo Kim,

    Corresponding author
    1. Bio/Nano Technology Laboratory, Department of Biological and Agricultural Engineering and Institute for Nanoscience and Engineering, University of Arkansas, Fayetteville, AR 72701 (USA)
    • Bio/Nano Technology Laboratory, Department of Biological and Agricultural Engineering and Institute for Nanoscience and Engineering, University of Arkansas, Fayetteville, AR 72701 (USA)
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  • Dr. Jeong-Hwan Kim,

    1. Bio/Nano Technology Laboratory, Department of Biological and Agricultural Engineering and Institute for Nanoscience and Engineering, University of Arkansas, Fayetteville, AR 72701 (USA)
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  • Prof. Russell Deaton

    1. Department of Computer Science and Computer Engineering, University of Arkansas, Fayetteville, AR 72701 (USA)
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  • This research has been supported in part by National Science Foundation grant number CMMI-0709121 (J.-W.K. and R.D.) and the Arkansas Biosciences Institute (J.-W.K.). We thank Ju Seok Lee for his assistance with DNA sample preparation, Hee-Jeung Kim for her assistance in image processing, and Min Kim for her artwork for the back cover picture.

Abstract

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One step at a time: DNA linkers were placed at defined locations and in defined 3D orientations on a colloidal nanoparticle. Because the implemented ligand-replacement strategy was carried out sequentially, DNA linkers maximally segregated, producing a nanoparticle with linkers at 90 or 180° angles (see picture). These building blocks should enable assembly of anisotropic nanostructures with precisely designed geometry and complex functionality.

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