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Keywords:

  • biphasic catalysis;
  • continuous flow;
  • multistep reactions;
  • oxindole;
  • α-arylation
Thumbnail image of graphical abstract

Facilitating chemistry: Key to the success of Pd-catalyzed α-arylation of oxindoles in continuous flow involved a biphasic system, a precatalyst, and a packed-bed microreactor. Furthermore, this reaction was integrated into a two-step continuous-flow sequence for rapid, modular, and efficient syntheses of 3,3-disubstituted oxindoles.