Alan Long, Hyoung Ik Lee and Bharathi Pandi are acknowledged for enriching discussions pertaining to organic and medicinal chemistry. Graphics: Michael J. Malaska. Background photo adapted from Public Health Image Library ID no. 9994 (CDC/Janice Haney Carr).
Isoxazole Functionalization Technologies Enable Construction of Tetracycline Derivatives†
Article first published online: 29 JUN 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 37, pages 8474–8477, September 5, 2011
How to Cite
Heasley, B. (2011), Isoxazole Functionalization Technologies Enable Construction of Tetracycline Derivatives. Angew. Chem. Int. Ed., 50: 8474–8477. doi: 10.1002/anie.201102480
- Issue published online: 1 SEP 2011
- Article first published online: 29 JUN 2011
- Manuscript Received: 10 APR 2011
- antimicrobial agents;
- bacterial resistance;
- seragakinone A;
Reactive response: Tetracyclines are potent antimicrobial agents—however, their high consumption level has contributed to the emergence of widespread bacterial resistance, which in turn stimulates the systematic search for new tetracycline analogues. In recent years, new synthetic methods have emerged that provide access to a broad range of tetracycline analogues.