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Keywords:

  • antimicrobial agents;
  • bacterial resistance;
  • isoxazole;
  • seragakinone A;
  • tetracycline
Thumbnail image of graphical abstract

Reactive response: Tetracyclines are potent antimicrobial agents—however, their high consumption level has contributed to the emergence of widespread bacterial resistance, which in turn stimulates the systematic search for new tetracycline analogues. In recent years, new synthetic methods have emerged that provide access to a broad range of tetracycline analogues.