Isoxazole Functionalization Technologies Enable Construction of Tetracycline Derivatives


  • Alan Long, Hyoung Ik Lee and Bharathi Pandi are acknowledged for enriching discussions pertaining to organic and medicinal chemistry. Graphics: Michael J. Malaska. Background photo adapted from Public Health Image Library ID no. 9994 (CDC/Janice Haney Carr).


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Reactive response: Tetracyclines are potent antimicrobial agents—however, their high consumption level has contributed to the emergence of widespread bacterial resistance, which in turn stimulates the systematic search for new tetracycline analogues. In recent years, new synthetic methods have emerged that provide access to a broad range of tetracycline analogues.