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Keywords:

  • natural products;
  • osmium;
  • oxidative cyclization;
  • oxocarbenium ions;
  • total synthesis
Thumbnail image of graphical abstract

To the point: The synthesis of the title compound was achieved with 24 % overall yield through a sequence that has just seven linear steps (see scheme). Key points are the facial selectivity displayed by an oxocarbenium ion derived from a ribopyranose system and an osmium-catalyzed oxidative cyclization that is compatible with several acid-sensitive groups.