An Additional Coordination Group Leads to Extremely Efficient Chiral Iridium Catalysts for Asymmetric Hydrogenation of Ketones

Authors

  • Prof. Jian-Hua Xie,

    Corresponding author
    1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
    • State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
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  • Xiao-Yan Liu,

    1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
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  • Jian-Bo Xie,

    1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
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  • Prof. Li-Xin Wang,

    1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
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  • Prof. Qi-Lin Zhou

    Corresponding author
    1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
    • State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China)
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  • We thank the National Natural Science Foundation of China, the National Basic Research Program of China (2010CB833300, 2011CB808600) for financial support.

Abstract

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What a turnover! An efficient chiral iridium catalyst that bears a tridentate spiro aminophosphine ligand catalyzes the asymmetric hydrogenation of ketones with excellent enantioselectivities (up to 99.9 % ee) and extremely high turnover numbers (TONs; as high as 4 550 000).

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