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Enantioselective Synthesis of (−)-Exiguolide by Iterative Stereoselective Dioxinone-Directed Prins Cyclizations†

  1. Erika A. Crane,
  2. Dr. Thomas P. Zabawa,
  3. Rebecca L. Farmer,
  4. Prof. Dr. Karl A. Scheidt*

Article first published online: 17 AUG 2011

DOI: 10.1002/anie.201102790

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 39, pages 9112–9115, September 19, 2011

Additional Information

How to Cite

Crane, E. A., Zabawa, T. P., Farmer, R. L. and Scheidt, K. A. (2011), Enantioselective Synthesis of (−)-Exiguolide by Iterative Stereoselective Dioxinone-Directed Prins Cyclizations. Angew. Chem. Int. Ed., 50: 9112–9115. doi: 10.1002/anie.201102790

Author Information

  1. Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Silverman Hall, Northwestern University, Evanston, IL 60208 (USA) http://chemgroups.northwestern.edu/scheidt/

*Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Silverman Hall, Northwestern University, Evanston, IL 60208 (USA) http://chemgroups.northwestern.edu/scheidt/

  1. †

    Financial support for this work was provided by the NCI (RO1 CA126827 and SPORE in Prostate Cancer P50 CA090386), the American Cancer Society (Research Scholar Award to K.A.S.) and Amgen. We are grateful to Boehringer-Ingelheim for the New Investigator Award in Organic Chemistry supporting T.P.Z. R.L.F. thanks the NIH for a predoctoral fellowship (F31CA138097). E.A.C. and R.L.F. thank the Malkin Scholars Program for additional support (Robert H. Lurie Comprehensive Cancer Center at Northwestern University). We would like to thank Dr. Andrew Mazar, Keith Macrenaris, Rich Ahn, and Elden Swindell (NU) for providing the cancer cell lines and cell culture technical support.

Publication History

  1. Issue published online: 15 SEP 2011
  2. Article first published online: 17 AUG 2011
  3. Manuscript Revised: 4 JUL 2011
  4. Manuscript Received: 21 APR 2011

Funded by

  • NCI. Grant Numbers: RO1 CA126827, SPORE in Prostate Cancer P50 CA090386
  • American Cancer Society
  • NIH. Grant Number: F31CA138097

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