Get access

Artificial Molecular Clamp: A Novel Device for Synthetic Polymerases

Authors

  • Dr. Yoshinori Takashima,

    1. Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560-0043 (Japan)
    Search for more papers by this author
  • Dr. Motofumi Osaki,

    1. Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560-0043 (Japan)
    Search for more papers by this author
  • Prof. Dr. Yoshihiro Ishimaru,

    1. Department of Functional Materials Science, School of Engineering, Saitama University (Japan)
    Search for more papers by this author
  • Dr. Hiroyasu Yamaguchi,

    1. Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560-0043 (Japan)
    Search for more papers by this author
  • Prof. Dr. Akira Harada

    Corresponding author
    1. Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560-0043 (Japan)
    2. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Sanban-cho Building, 4F, 5 Sanban-cho, Chiyoda-ku, Tokyo 102-0075 (Japan)
    • Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560-0043 (Japan)
    Search for more papers by this author

  • This research was supported by the CREST project, Japan Science and Technology Agency. The authors thank Seiji Adachi (Osaka University) for his helpful advice on the measurement of 2D NOESY spectra.

Abstract

original image

Synthetic polymerases composed of a cyclodextrin (CD) dimer yield high-molecular-weight polymers of cyclic esters without using solvents and co-catalysts. One CD moiety is attached to the active site of a supramolecular catalyst and propagates the polymerization by serving as artificial molecular clamp (see picture). The other CD moiety initiates the ring-opening polymerization.

Ancillary