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Sequential SPECT and Optical Imaging of Experimental Models of Prostate Cancer with a Dual Modality Inhibitor of the Prostate-Specific Membrane Antigen


  • We thank Dr. David Wasserman of LI-COR Biosciences for use of their equipment and guidance in the in vivo study. We also thank U24 CA92871, R01 CA134675 and K25 CA148901 for financial support. SPECT=single photon emission computed tomography.


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One reagent for two techniques: Compound [111In]1 provides a platform for sequential radionuclide and optical imaging of prostate cancer through targeting of the prostate-specific membrane antigen. Because the same subject can be dual-imaged after one injection of the agent, these findings support rapid clinical translation.