Generous financial support from the National Institutes of Health (GM-46059) is gratefully acknowledged. The Bruker 400 MHz instrument used in this work was purchased with funding from the National Institutes of Health (GM 1S10RR13886-01). We are grateful to Georgiy Teverovskiy (MIT) for initial studies on DFT calculations and to Sophie Rousseaux (MIT) for helpful discussions.
Palladium(0)-Catalyzed Intermolecular Amination of Unactivated CH Bonds†
Article first published online: 2 AUG 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 37, pages 8647–8651, September 5, 2011
How to Cite
Pan, J., Su, M. and Buchwald, S. L. (2011), Palladium(0)-Catalyzed Intermolecular Amination of Unactivated CH Bonds. Angew. Chem. Int. Ed., 50: 8647–8651. doi: 10.1002/anie.201102880
- Issue published online: 1 SEP 2011
- Article first published online: 2 AUG 2011
- Manuscript Revised: 30 MAY 2011
- Manuscript Received: 26 APR 2011
- National Institutes of Health. Grant Numbers: GM-46059, GM 1S10RR13886-01
- CH amination;
- homogeneous catalysis;
Filling out the space: The title reaction of unactivated CH bonds using aryl amines as the nitrogen source is disclosed (see scheme; dba=dibenzylideneacetone, Tf=trifluoromethanesulfonyl). Either the CN cross-coupling product or the CH amination product could be accessed selectively by adjusting the steric environment of the substrate.