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Tumor-Targeting Gold Particles for Dual Computed Tomography/Optical Cancer Imaging

Authors

  • In-Cheol Sun,

    1. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
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  • Dae-Kyung Eun,

    1. Research Institute of Advanced Materials (RIAM), Department of Materials Science and Engineering, Seoul National University, San 56-1, Sillim, Gwanak, Seoul, 151-744 (Korea)
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  • Dr. Heebeom Koo,

    1. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
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  • Dr. Chang-Yong Ko,

    1. Department of Biomedical Engineering, Yonsei Univeristy, Wonju, Ganwondo 220-710 (Korea)
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  • Dr. Han-Sung Kim,

    1. Department of Biomedical Engineering, Yonsei Univeristy, Wonju, Ganwondo 220-710 (Korea)
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  • Dr. Dong Kee Yi,

    1. Division of Bionanotechnology, Gachon Bionano Institute, Kyungwon University, Geonggi-do, 461-701 (Korea)
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  • Dr. Kuiwon Choi,

    1. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
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  • Dr. Ick Chan Kwon,

    1. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
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  • Dr. Kwangmeyung Kim,

    Corresponding author
    1. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
    • Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
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  • Dr. Cheol-Hee Ahn

    Corresponding author
    1. Research Institute of Advanced Materials (RIAM), Department of Materials Science and Engineering, Seoul National University, San 56-1, Sillim, Gwanak, Seoul, 151-744 (Korea)
    • Research Institute of Advanced Materials (RIAM), Department of Materials Science and Engineering, Seoul National University, San 56-1, Sillim, Gwanak, Seoul, 151-744 (Korea)
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  • We thank the late Prof. Tae Gwan Park for valuable discussion about this research. This work was financially supported by the Real-Time Molecular Imaging Project, GRL Program of MEST, Intramural Research Program of KIST, M.D.-Ph.D. Program (2010-0019863, 2010-0019864), and the Basic Science Research Program (2010-0027955) of MEST.

Abstract

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Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.

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