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Detection of DNA–Ligand Binding Oscillations by Stokes-Shift Measurements


  • We thank the National Science Foundation for grant CHE-0845736 to S.A.C., the Deutsche Forschungsgemeinschaft for grant ER 154/9-1 to N.P.E., and the Chinese Scholarship Council for a scholarship to X.-X.Z.


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Riding the waves: In a DNA–ligand complex, the time-dependent Stokes shift shows initial oscillation. Molecular dynamics simulations help assign this ripple to coherent in/out motion of the ligand together with breathing of the minor groove (see picture).

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