Deconstruction of Capsules Using Chiral Spacers

Authors

  • Dr. Yoshihiro Yamauchi,

    1. The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
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  • Prof. Dariush Ajami,

    1. The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
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  • Ji-Yeon Lee,

    1. The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
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  • Prof. Julius Rebek Jr.

    Corresponding author
    1. The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    • The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
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  • We are grateful for financial support from the NSF/CHE 1037590 and the Skaggs Institute. Y.Y. thanks the JSPS for a Research Fellowship for Young Scientists.

Abstract

original image

Interconvertible host: Extended cavitands and capsules that recognize n-alkanes were generated using N-methyl glycoluril as a chiral spacer. The two host assemblies were interconverted by factors such as temperature, concentration, and guest length (see scheme).

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