Enantioselective Metal-Free Diamination of Styrenes


  • We thank Fundación ICIQ, the Consolider INTECAT 2010 (Project CSD2006-0003), the Alexander von Humboldt Foundation (fellowship to C.R.), and the French MESR (fellowship to A.L.) for financial support, and Dr. Á. Iglesias for discussions.


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Metal-free and asymmetric: The first enantioselective diamination of styrenes simply requires a chiral hypervalent iodine(III) reagent as an oxidant and bismesylimide as a nitrogen source (see scheme, Ms=methanesulfonyl). The reaction proceeds under mild conditions and with high enantiomeric excess.