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Keywords:

  • annulation;
  • diastereoselectivity;
  • metathesis;
  • total synthesis;
  • transition metals
Thumbnail image of graphical abstract

All together: A concise strategy for the first diastereoselective total synthesis of (±)-schindilactone A is reported. The synthesis features a ring-closing metathesis, a thiourea/cobalt-catalyzed Pauson–Khand reaction, and a thiourea/palladium-catalyzed carbonylative annulation reaction. The chemistry can be applied to the synthesis of structures related to schindilactone A.