These authors contributed equally to this work.
Diastereoselective Total Synthesis of (±)-Schindilactone A†
Article first published online: 7 JUL 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 32, pages 7373–7377, August 1, 2011
How to Cite
Xiao, Q., Ren, W.-W., Chen, Z.-X., Sun, T.-W., Li, Y., Ye, Q.-D., Gong, J.-X., Meng, F.-K., You, L., Liu, Y.-F., Zhao, M.-Z., Xu, L.-M., Shan, Z.-H., Shi, Y., Tang, Y.-F., Chen, J.-H. and Yang, Z. (2011), Diastereoselective Total Synthesis of (±)-Schindilactone A. Angew. Chem. Int. Ed., 50: 7373–7377. doi: 10.1002/anie.201103088
We are grateful to Prof. Handong Sun for a sample of the natural product schindilactone A, and to Prof. Junmin Quan for his support of computational experiments. This work was supported by grants from the National Basic Research Program (973 Program, Grant 2010CB833201), the National Science and Technology Major Project “Development of Key Technology for the Combinatorial synthesis of Privileged Scaffolds” (2009ZX09501-012), and the National Science Foundation of China (20821062, 20832003 and 20902007).
- Issue published online: 25 JUL 2011
- Article first published online: 7 JUL 2011
- Manuscript Received: 5 MAY 2011
- National Basic Research Program
- National Science and Technology Major Project “Development of Key Technology for the Combinatorial synthesis of Privileged Scaffolds”
- National Science Foundation of China
- total synthesis;
- transition metals
All together: A concise strategy for the first diastereoselective total synthesis of (±)-schindilactone A is reported. The synthesis features a ring-closing metathesis, a thiourea/cobalt-catalyzed Pauson–Khand reaction, and a thiourea/palladium-catalyzed carbonylative annulation reaction. The chemistry can be applied to the synthesis of structures related to schindilactone A.