Communication

Synthetic Polymers for Simultaneous Bacterial Sequestration and Quorum Sense Interference†

  1. Xuan Xue1,
  2. Dr. George Pasparakis1,
  3. Dr. Nigel Halliday3,
  4. Dr. Klaus Winzer3,
  5. Prof. Steven M. Howdle4,
  6. Dr. Christopher J. Cramphorn5,
  7. Prof. Neil R. Cameron5,
  8. Dr. Paul M. Gardner2,
  9. Prof. Benjamin G. Davis2,*,
  10. Dr. Francisco Fernández-Trillo1,*,
  11. Prof. Cameron Alexander1,*

Article first published online: 16 SEP 2011

DOI: 10.1002/anie.201103130

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 42, pages 9852–9856, October 10, 2011

Additional Information

How to Cite

Xue, X., Pasparakis, G., Halliday, N., Winzer, K., Howdle, S. M., Cramphorn, C. J., Cameron, N. R., Gardner, P. M., Davis, B. G., Fernández-Trillo, F. and Alexander, C. (2011), Synthetic Polymers for Simultaneous Bacterial Sequestration and Quorum Sense Interference. Angew. Chem. Int. Ed., 50: 9852–9856. doi: 10.1002/anie.201103130

Author Information

  1. 1

    School of Pharmacy, The University of Nottingham, University Park, Nottingham NG7 2RD (UK)

  2. 2

    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA (UK)

  3. 3

    School of Molecular Medical Sciences, Centre for Biomolecular Sciences, The University of Nottingham, University Park, Nottingham NG7 2RD (UK)

  4. 4

    School of Chemistry, The University of Nottingham, University Park, Nottingham NG7 2RD (UK)

  5. 5

    Biophysical Sciences Institute and Department of Chemistry, Durham University, University Science Laboratories, South Road, Durham DH1 3LE (UK)

*Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA (UK)

  1. †

    We thank the UK EPSRC and BBSRC (Grants EP/G042462/1, EP/D022347/1, D021847/1, and BB/F01855X/1) and the University of Nottingham, UK, for funding. We thank Bonnie Bassler (Department of Molecular Biology, Princeton University) for the gift of V. harveyi strain MM32, Adrienne Davis and Shazhad Aslam (School of Chemistry, University of Nottingham) and Istvan Pelczer (Department of Chemistry, Princeton University) for help and useful discussions regarding 11B NMR spectroscopy, and Natalio Krasnogor, Leung Lui (School of Computer Sciences, University of Nottingham), and Chunjuan Liu (Department of Chemistry, University of Oxford) for helpful discussions.

Publication History

  1. Issue published online: 6 OCT 2011
  2. Article first published online: 16 SEP 2011
  3. Manuscript Received: 6 MAY 2011

Funded by

  • UK EPSRC
  • BBSRC. Grant Numbers: EP/G042462/1, EP/D022347/1, D021847/1, BB/F01855X/1
  • University of Nottingham, UK

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Keywords:

  • cell adhesion;
  • luminescence;
  • polymers;
  • quorum sensing;
  • therapeutics
Thumbnail image of graphical abstract

Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.

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