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Improved Ruthenium-Catalyzed Amination of Alcohols with Ammonia: Synthesis of Diamines and Amino Esters


  • This work has been supported by Evonik, the Deutsche Forschungsgemeinschaft (Leibniz prize to M.B.), and the Alexander von Humboldt Foundation (grant to Z.M.).


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Diamination of diols: The first homogeneously catalyzed diaminations of primary and secondary diols with ammonia give the corresponding diamines. Other primary as well as secondary alcohols including hydroxy-substituted esters can also be efficiently converted to primary amines. This atom-efficient and selective amination method proceeds in an ammonia atmosphere without additional hydrogen sources.