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Efficient Synthesis and Applications of Peptides containing Adenylylated Tyrosine Residues



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The enzyme DrrA of the human pathogen Legionella pneumophila adenylylates specifically a tyrosine of the GTPase Rab1. An efficient synthesis route using Fmoc solid phase peptide synthesis led to Tyr-adenylylated peptides and allowed the generation of mono-selective polyclonal antibodies against this post-translational modification.