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Enantioselective Enzymatic Desymmetrization of Prochiral Allenic Diols


  • This work was supported by the Fonds der Chemischen Industrie (Liebig Fellowship), the German Academic Exchange Service DAAD, the Swedish Research Council, and the K&W Wallenberg Foundation as well as by Carbolution Chemicals.


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Crude lipase from porcine pancreas acts as a highly efficient biocatalyst in the enantioselective transesterification of prochiral allendiols. Following a simple synthetic protocol, highly functionalized axially chiral allenes are obtained in high yields and excellent enantiopurity (see scheme).