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Keywords:

  • allylation;
  • allylic alcohol;
  • chiral counteranions;
  • palladium;
  • phosphates
Thumbnail image of graphical abstract

Triple catalysis: The title reaction between α-branched aldehydes and allylic alcohols, which generates all-carbon quaternary stereogenic centers, constitutes the first asymmetric Tsuji–Trost-type α-allylation of carbonyl compounds with allylic alcohol (see scheme). This reaction is catalyzed by three different species, [Pd(PPh3)4], the chiral Brønsted acid TRIP, and benzhydryl amine.