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Second-Generation Total Synthesis of Spirastrellolide F Methyl Ester: The Alkyne Route

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  • Generous financial support by the MPG and the Fonds der Chemischen Industrie (Kekulé stipends to S.B. and A.A.) is gratefully acknowledged. We thank S. Schulthoff for skillful technical assistance.

Abstract

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Outlandish: The spiroketal embedded in spirastrellolide F methyl ester is a daring site for ring closure, yet it has allowed the power of catalytic alkyne scission and activation to be showcased (see scheme). An improved strategy for the introduction of the labile side chain was also developed.

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