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Amino Acid-Based Reoxidants for Aminohydroxylation: Application to the Construction of Amino Acid–Amino Alcohol Conjugates


  • We thank the EPSRC, the European Union, the SNSF, and AstraZeneca for supporting this project. We also thank the Oxford Chemical Crystallography Service for the use of their instrumentation.


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A viable nitrogen source for the aminohydroxylation reaction of terminal alkenes: By adding a N-O based reoxidant onto an amino acid acyl carbon atom, compounds were obtained that facilitated catalytic turnover and also promoted the conjugation of an amino acid with an alkene. High levels of regioselectivity were observed, as well as good stereoselectivity induced by catalytic amounts of a chiral ligand.

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