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Keywords:

  • circadian rhythm;
  • DNA recognition;
  • gene expression;
  • phase resetting;
  • zinc finger proteins
Thumbnail image of graphical abstract

I got rhythm: The circadian clock is driven by transcription–translation feedback loops. The circadian time can be altered by creating an artificial zinc finger protein specifically binding to the glucocorticoid responsive element (GRE) on the Period1 promoter (see picture; DD=destabilizing domain, AD=activation domain). This artificial protein directly controls the clock machinery.