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Keywords:

  • asymmetric synthesis;
  • Birch reduction.;
  • C[BOND]C bond formation;
  • homogeneous catalysis;
  • palladium
Thumbnail image of graphical abstract

Walk on the same side! The title reaction occurs by means of highly stereospecific 1,3-metal migration. The starting carboxylic acids are readily prepared by Birch reduction, and the developed protocol provides an efficient route to enantiomerically pure 5-arylated-1,3-cyclohexadiene derivatives (see scheme).