Synthesis of Trifluoroethyl-Substituted Ketones from Aldehydes and Cyclohexanones


  • We are grateful to the Swiss National Foundation and the SSCI for a fellowship to B.M. Dr. Schweizer is acknowledged for crystallographic analyses.


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A trifluoromethylated symphony! A new transformation involving trifluoromethyl diazomethane generated in situ has been developed that allows direct access to trifluoroethyl ketone derivatives from aldehyde and cyclohexanone compounds (see scheme).