Conjugation of Porphyrin to Nanohybrid Cerasomes for Photodynamic Diagnosis and Therapy of Cancer

Authors


  • This research was financially supported by the National Natural Science Foundation of China (grant numbers NSFC-30970829 and 20977021).

Abstract

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Shining light on cancer cells: A cerasomal photosensitizer of high stability and loading efficiency was developed by conjugation of a porphyrin molecule to an organoalkoxysilylated lipid followed by sol–gel and self-assembly processes (see picture). This nanoformulation showed intrinsic fluorescence and significant damage to tumor cells under photoirradiation.

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