This material is based on work supported by the National Science Foundation under the Center for Chemical Innovation in Stereoselective CH Functionalization (CHE-0943980) and by the National Institutes of Health (GM080337).
Computationally Guided Stereocontrol of the Combined CH Functionalization/Cope Rearrangement†
Article first published online: 30 AUG 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 40, pages 9370–9373, September 26, 2011
How to Cite
Lian, Y., Hardcastle, K. I. and Davies, H. M. L. (2011), Computationally Guided Stereocontrol of the Combined CH Functionalization/Cope Rearrangement. Angew. Chem. Int. Ed., 50: 9370–9373. doi: 10.1002/anie.201103568
- Issue published online: 21 SEP 2011
- Article first published online: 30 AUG 2011
- Manuscript Received: 24 MAY 2011
- National Institutes of Health. Grant Numbers: GM080337, CHE-0943980
- CH functionalization;
- Cope rearrangement;
Diastereoselectivity in control: The synthetic utility of the CH functionalization/Cope rearrangement reaction has been greatly expanded by the design of substrates that will react through a boat transition state instead of a chair transition state. The products are formed with the opposite diastereoselectivity as previously obtained (see scheme, ABSA= acetamidobenzenesulfonylazide).