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Keywords:

  • allylic substitution;
  • asymmetric catalysis;
  • boron;
  • copper;
  • N-heterocyclic carbenes
Thumbnail image of graphical abstract

The asymmetric allylic substitution of allyl phosphates with aryl- and alkenylboronates catalyzed by a copper/N-heterocyclic carbene complex was developed and the γ-substitution products were obtained with high enantioselectivity (see scheme). To account for the observed influence of the reaction parameters a possible catalytic cycle for this process was proposed.