SEARCH

SEARCH BY CITATION

Keywords:

  • cross-coupling;
  • Negishi coupling;
  • palladium;
  • Suzuki–Miyaura coupling;
  • zirconacycles
Thumbnail image of graphical abstract

Two Nobel couplings: The synthesis of tri- and tetraalkylated olefins has been achieved (see scheme). These multialkylated olefins were prepared by the zirconocene-mediated carbometalation of 1-alkynylboronates and subsequent sequential C[BOND]C bond formation with Negishi and Suzuki–Miyaura cross-coupling reactions using β-hydrogen-containing alkylzinc reagents and alkyl electrophiles as coupling partners.