This work was generously supported by the Deutsche Akademie der Naturforscher Leopoldina (Bundesministerium für Bildung und Forschung BMBF-LPD 9901/8-158) and the ETH Zürich.
Photolyase-like Repair of Psoralen-Crosslinked Nucleic Acids†
Article first published online: 29 AUG 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 40, pages 9483–9486, September 26, 2011
How to Cite
Stafforst, T. and Hilvert, D. (2011), Photolyase-like Repair of Psoralen-Crosslinked Nucleic Acids. Angew. Chem. Int. Ed., 50: 9483–9486. doi: 10.1002/anie.201103611
- Issue published online: 21 SEP 2011
- Article first published online: 29 AUG 2011
- Manuscript Received: 26 MAY 2011
- Deutsche Akademie der Naturforscher Leopoldina. Grant Number: 9901/8-158
- ETH Zürich
- DNA repair;
- peptide nucleic acids;
Psoralen-derived photolesions are efficiently repaired by a photolyase-like mechanism. The removal of the interstrand crosslink by photoelectron injection confers control over biochemical processes by light (see picture). This paves the way to new, site-selective uncaging applications, as demonstrated with a primer extension assay.